Javier Montenegro

Updated CV


Javier Montenegro received his master degree (2003) and PhD (2009) from the University of Santiago de Compostela, under the direction of Prof. Susana López, working in the field of synthetic retinoids and their evaluation as artificial pigments in bacteriorhodopsins. In 2005 he was a visiting scientist in the group of Prof. Steven Ley at Cambridge University (Total Synthesis). In 2007 he was a visiting scientist at the Scripps Research Institute (La Jolla) working with Prof. Reza M. Ghadiri in prebiotic chemistry and  supramolecular dynamic polymers. In 2009 he moved to the University of Geneva for postdoctoral studies with Prof. Stefan Matile in biosensing, synthetic transport systems and controlled delivery. In 2012 he returned to Spain with Juan de la Cierva and a Ramon y Cajal at Organic Chemistry Department and then promoted to Profesor Titular and Oportunius Researcher (2020) as PI in the CIQUS at the University of Santiago de Compostela. He has received different prestigious awards including: a Starting Grant from the ERC (2015), a Young Investigator Grant of the Human Frontier Science Program (2017), JSP Fellow 52th Bürgenstock Conference (2017), the Prize of Young Investigators of the Spanish Royal Society of Chemistry (2018) and the Prize of Young Research Group Leaders in Chemical Biology of the RSEQ (2019).

Selected Publications

"Metallacarborane Cluster Anions of the COSAN-Type as Chaotropic Carriers for Transmembrane and Intracellular Delivery of Cationic Peptides" Chen Y., Barba-Bon, A., Grüner, B., Winterhalter, M., Aksoyoglu, M. A., Pangeni, S., Ashjari, M., Brix, K., Salluce, G., Folgar-Cameán, Y., Montenegro, J., Nau, W., W. J. Am. Chem. Soc., 2023, 145, 24, 13089–13098.

"Photoswitchable Calixarene Activators for Controlled Peptide Transport Across Lipid Membranes" Martins, J., Raimundo, B., Rioboo, A., Folgar-Cameán, Y., Montenegro, J., Basílio, N., J. Am. Chem. Soc., 2023, 145, 24, 13126–13133.

"Boron Clusters as Broadband Membrane Carriers." Barba-Bon, A.; Salluce, G.; Lostalé-Seijo, I.; Assaf, K. I.; Hennig, A.; Montenegro, J.; Nau, W.  Nature, 2022, 603, 637–642.

“Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets" Booth, R.; Insua, I.; Ahmed, S.; Rioboo, A.; Montenegro, J.; Nature Communications 2021, 12, 6421

“Spatially controlled supramolecular polymerization of peptide nanotubes by microfluidics” Méndez-Ardoy, A.; Bayón-Fernández, A.; Yu, Z.; Abell, C.; Granja, J.R.; Montenegro, J.; Angew. Chem. Int. Ed. 2020, 59, 6902-6908.

“1D to 2D Self Assembly of Cyclic Peptides” Insua, I., Montenegro, J.; J. Am. Chem. Soc., 2020, 142, 300-307.

“Synthetic materials at the forefront of gene delivery” Lostalé-Seijo, I., Montenegro, J. Nat. Rev. Chem. 2018, 2, 258–277.

“Peptide/Cas9 Nanostructures for Ribonucleoprotein Cell Membrane Transport and Gene Edition” Lostalé-Seijo, I.; Louzao, I.; Juanes, M.; Montenegro, J. Chem. Sci., 2017, 8, 7883–8466.

Experimental evidence for the functional relevance of anion-π interactions.” Dawson, R. E.; Hennig, A.; Weimann, D. P.; Emery, D.; Ravikumar, V.; Montenegro, J.; Takeuchi, T.; Gabutti, S.; Mayor, M.; Mareda, J.; Schalley, C. A.; Matile, S.  Nat. Chem., 2010, 2, 533–538.

At the interphase between Organic Synthetic and Supramolecular Chemistry applied to Biology, Membrane Transport and the Discovery of new materials. Focused in controlled delivery of nucleic acids and proteins and the topological control of supramolecular assemblies for fucntional applications such as sensing, nanotechnology and tubular composites.