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Javier Montenegro

Research

Javier Montenegro received his master degree (2003) and PhD (2009) from the University of Santiago de Compostela, under the direction of Prof. Susana López, working in the field of synthetic retinoids. In 2005 he was a visiting scientist in the group of Prof. Steven Ley at Cambridge University (Total Synthesis). In 2007 he was a visiting scientist at the Scripps Research Institute (La Jolla) working with Prof. Reza M. Ghadiri in prebiotic chemistry and  supramolecular dynamic polymers. In 2009 he moved to the University of Geneva for postdoctoral studies with Prof. Stefan Matile in biosensing, synthetic transport systems and controlled delivery. In 2012 he returned to Spain with Juan de la Cierva and a Ramon y Cajal at Organic Chemistry Department and he was appointed PI in the CIQUS in 2017 at the University of Santiago de Compostela. He has received several of the most prestigious international awards including: a Starting Grant from the ERC (2015), a Young Investigator Grant of the Human Frontier Science Program (2017), JSP Fellow 52th Bürgenstock Conference (2017), the Prize of Young Investigators of the Spanish Royal Society of Chemistry (2018) and the Prize of Young Research Group Leaders in Chemical Biology of the RSEQ (2019).


Selected Publications


“Spatially controlled supramolecular polymerization of peptide nanotubes by microfluidics” Méndez-Ardoy, A.; Bayón-Fernández, A.; Yu, Z.; Abell, C.; Granja, J.R.; Montenegro, J.; Angew. Chem. Int. Ed., 2020, In press.


“1D to 2D Self Assembly of Cyclic Peptides” Insua, I., Montenegro, J.; J. Am. Chem. Soc., 2020, 142, 300-307.


“Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy” Jiang, B.; Aliyan, A.; Cook, N. P.; Augustine, A.; Bhak, G.; Maldonado, R.; Smith, McWilliams, A. D.; Flores, E.; Mendez, N. G.; Godoy, F.; Montenegro, J.; Moreno-Gonzalez, I. Martí. A. A.;  J. Am. Chem. Soc. 2019, 141, 15605-15610.


“Supramolecular Caging for Cytosolic Delivery of Anionic Probes” Fernández-Caro, Lostalé-Seijo, I.; Martínez-Calvo, M.; Mosquera, J.; Mascareñas, J. L.;  Chem. Sci., 2019, 10, 8930-8938.


“Synthetic materials at the forefront of gene delivery” Lostalé-Seijo, I., Montenegro, J. Nat. Rev. Chem. 2018, 2, 258–277


“Peptide/Cas9 Nanostructures for Ribonucleoprotein Cell Membrane Transport and Gene Edition” Lostalé-Seijo, I.; Louzao, I.; Juanes, M.; Montenegro, J. Chem. Sci., 2017, 8, 7883–8466.


In situ” Functionalized Polymers for siRNA Delivery”, Priegue, J. M.; Crisan, D. N.; Martínez-Costas, J;  Granja, J. R.; Fernandez-Trillo, F.; Montenegro, J.,Angew. Chem. Int. Ed. 2016, 55, 7492-7495.


Coupling of Peptides and Carbon Nanotubes” Montenegro, J.,* Vázquez-Vázquez, C., Kalinin, A., Geckeler, K. E., & Granja, J. R. Coupling of carbon and Peptide nanotubes. J. Am. Chem. Soc., 2014, 136, 2484–2491.


Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes.” Montenegro, J.; Ghadiri, M. R.; Granja, J. R. Acc. Chem. Res., 2013, 46, 2955–2965.


Dynamic Amphiphile Libraries To Screen for the “Fragrant” Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts.” Gehin, C.; Montenegro, J.; Bang, E.-K.; Cajaraville, A.; Takayama, S.; Hirose, H.; Futaki, S.; Matile, S.; Riezman, H. J. Am. Chem. Soc., 2013, 135, 9295–9298.


Experimental evidence for the functional relevance of anion-π interactions.” Dawson, R. E.; Hennig, A.; Weimann, D. P.; Emery, D.; Ravikumar, V.; Montenegro, J.; Takeuchi, T.; Gabutti, S.; Mayor, M.; Mareda, J.; Schalley, C. A.; Matile, S.  Nat. Chem., 2010, 2, 533–538.

At the interphase between organic synthetic and supramolecular chemistry applied to biological systems and the Discovery of new materials. Focused in the topological control of supramolecular assemblies for broad applications such as differential sensing, nanotechnology, controlled delivery and tubular templated composites.